George T. Somogyi, M.D., Ph.D.

Faye Chiou-Tan, M.D.

Professor
Director, Scott Department of Urology Neurourology Laboratory

Medical School: Semmelweis University of Medicine, Budapest Hungary
Graduate School: Hungarian Academy of Sciences, Budapest Hungary
Postgraduate Training: Neuropharmacology, Dalhousie University, Canada

Research Interests: Muscarinic and adrenergic facilitatory mechanisms in peripheral nerves innervating the bladder, central transmitter release patterns associated with the development of detrusor hyperreflexia, and evaluation of efferent and afferent effects of botulinum toxin on the lower urinary tract.

Interaction of nicotinic and purinergic receptors in the bladder smooth muscle. Afferent effect of muscarinic and nicotinic receptor induced release of ATP and NO in the bladder urothelium.

Significant Professional Activities:

Pfizer International Cardura Award, 2002

Selected Publications:

Vemulakonda, V. M., Somogyi, G. T., Kiss, S., Salas, N. A., Boone, T. B., Smith, C. P.: Inhibitory effect of intravesically applied botulinum toxin A in chronic bladder inflammation. J Urology, 173: 621-624, 2005.

Szigeti, G. P., Somogyi, G. T., Csernoch, L., Szell, E. A.: Age-dependence of the spontaneous activity of the rat urinary bladder. J Muscle Res Cell Motil, 26: 23-29, 2005.

Smith, C. P., Vemulakonda, V. M., Kiss, S., Boone, T. B., Somogyi, G. T.: Enhanced ATP release from rat bladder urothelium during chronic bladder inflammation: Effect of botulinum toxin A. Neurochemistry International, 47: 291-297, 2005.

Khera, M., Somogyi, G. T., Salas, N. A., Kiss, S., Boone, T. B., Smith, C. P.: In vivo effects of botulinum toxin A on visceral seensory function i chronic spinal cord-injured rats. Urology, 66: 208-212, 2005.

Khera, M., Somogyi, G. T., Salas, N. A., Kiss, S., Boone, T. B., Smith, C.: In vivo effects of botulinum toxin A on visceral sensory function in chronic spinal cord-injured rats. Urology, 66: 208-212, 2005.

Smith, C. P., Somogyi, G. T., Boone, T. B.: Botulinum toxin in urology: evaluation using an evidence-based medicine approach. Natl Clin Practice, 1: 31-37, 2004.

Smith, C. P., Radziszewski, P., Borkowski, A., Somogyi, G. T., Boone, T. B., Chancellor, M.: Botulinum toxin -A has antinociceptive effects in treating interstitial cystitis. Urology, 64: 871-875, 2004.

Smith, C. P., Somogyi, G. T., Chancellor, M. B., Appell, R.: A case for botulinum toxin-A in idopathic bladder overactivity. Curr Urol Rep, 5: 432-436, 2004.

Lai, H. H., Boone, T. B., Yang, G., Smith, C. P., Kiss, S., Thompson, T. C., Somogyi, G. T.: Loss of caveolin-1 expression is associated with disruption of muscarinic cholinergic activities in the urinary bladder. Neurochemistry International, 45: 1185-1193, 2004.

Khera, M., Somogyi, G. T., Kiss, S., Boone, T. B., Smith, C. P.: Botulinum toxin A inhibits ATP release from bladder urothelium after chronic spinal cord injury. Neurochem Int, 45: 987-993, 2004.

Smith, C. P., Boone, T. B., DeGroat, W. C., Chancellor, M., Somogyi, G. T.: Effect of stimulation intensity and botulinum toxin isoform on rat bladder strip contractions. Brain Res Bull, 61: 165-171, 2003.

Cannon, T. W., Lee, J. Y., Somogyi, G., Pruchnic, R., Smith, C. P., Huard, J., Chancellor, M. B.: Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra. Urology, 62: 958-963, 2003.

Smith, C. P., Somogyi, G. T., Chancellor, M. B.: Botulinum toxin treatment of urethral and bladder dysfunction. International Braz J. Urol., 28: 545-552, 2002.

Smith, C. P., Somogyi, G. T., Chancellor, M.: Botulinum toxin: poisoning the spastic bladder and urethra. Reviews in Urology, 4: 61-68, 2002.

Smith, C. P., Somogyi, G. T., Chancellor, M. B.: Emerging role of botulinum toxin in the treatment of neurogenic and non-neurogenic voiding dysfunction. Current Urology Reports, 3: 382-387, 2002.

Smith, C. P., Somogyi, G. T., Bird, E. T., Chancellor, M. B., Boone, T. B.: Neurogenic bladder model for spinal cord injury: spinal cord microdialysis and chronic urodynamics. Brain Research: Brain Research Protocols, 9: 57-64, 2002.